Surfactants Shown to Impair the Skin Barrier

STOCKHOLM – New research shows that surfactants in household cleaning products disrupt the human skin barrier, according to SciBase Holding AB, a developer of AI-based devices for detection and prevention in dermatology.

In the study, human ex vivo skin samples were exposed to Sodium dodecyl sulfate (SDS), a surfactant in household cleaning products which is known to impair the barrier.

Conducted with the Swiss Institute of Allergy and Asthma Research (SIAF) in Davos, Switzerland, Nevisense and its underlying Electrical Impedance Spectroscopy (EIS) technology showed changes in the skin barrier and detected that short-term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as well as an effect on N-acetylcysteine (NAC) and nicotinamide (NAM) to promote recovery of skin barrier function.

Skin barrier research is an expanding area in dermatology. Disruption of skin barrier function plays a key role in the development and severity of contact dermatitis from chemical substances

"We are happy to see that Nevisense and EIS-technology continue to provide value in this type of research," said Pia Renaudin, CEO of SciBase. “This study further strengthens the role of Nevisense as an effective research device and show the potential to become the state-of-the-art research tool within the skin barrier research.”

The full results of the study have now been published in the scientific journal “Allergy” and entitled "Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms."

SciBase is a global medical technology company that develops, manufactures, and commercializes Nevisense, a unique point-of-care platform that combines AI and advanced EIS technology to elevate diagnostic accuracy, ensuring proactive skin health management.

Built on more than 20 years of research at Karolinska Institute in Stockholm, Sweden, SciBase is a leader in dermatological advancements.

Learn more at www.scibase.com.